Genetics -> PGD
Pre-implantation Genetic Diagnosis
What is a PGD?
Pre-implantation genetic diagnosis (PGD) is mostly used in assisted reproduction. It involves the examination of embryos before implantation for any abnormalities. It is recommended for pregnancies in which offspring are at risk of having serious genetic disorders. In the pre-implantation genetic diagnosis, embryos are tested in their early stages and sometimes even before fertilization. PGD was first used in 1989 in America to determine the presence of genetic defects. Congenital abnormalities and genetic defects occur in about 5% of all live births. In assisted reproduction, the chances of it are slightly higher when compared to normal pregnancies. PGD helps ensure healthy pregnancies by offering genetic screening of embryos before implantation so the healthiest one is implanted. It also aids in preventing hereditary diseases, thus alleviating the chances of pregnancy termination. Genetic counsellors play a vital role in PGD. Our team of genetic counsellors guide the patients so they can make informed decisions.
The Journey of PGD: From Consultation to Success
The procedure of PGD comprises several steps performed by experts.
Genetic Testing Method: Various testing methods are used in PGD for genetic evaluation. Techniques such as PCR, FISH, next-generation sequencing (NGS), or comparative genomic hybridization (CGH) enable the specialist to select the healthiest embryo for implantation.
Embryo Biopsy: Embryo biopsy is a critical procedure in which cells are gently removed from a blastocyst, ensuring healthy embryo viability. It is done to analyze the DNA, which gives us insights to improve the chances of a successful and healthy pregnancy.
Selection and Transfer: After the embryos are analyzed for congenital abnormalities and genetic disorders through PGD, the healthiest embryo is selected for implantation. The selected embryo is implanted into the uterus using a thin catheter. PGD improve the chances of successful pregnancy.
Ethical Consideration: Couples are concerned about genetic data privacy, responsible genetic testing and reproductive choices. Our team ensures confidentiality and provides genetic counselling, empowering our patients to make autonomous and informed decisions.
Genetic Analysis: Genetic Analysis is performed to ensure the genetic health of embryos and to examine them for chromosomal abnormalities and specific genetic mutations. The laboratory techniques used for this purpose include:
- Polymerase chain reaction (PCR).
- Next-generation sequencing (NGS).
- Single nucleotide polymorphism (SNP).
- Fluorescence in-situ hybridization (FISH).
- Comparative genomic hybridization (CGH).
PGD Success Factors
Genetic Disorder Prevention
The success rate of PGD is about 90-95%, but it varies with maternal age, embryo quality, specific genetic condition the embryo is screened for, couple’s test results, and specialist’s expertise.
Embryo Viability
The genetic characteristics of an embryo are studied through PGD before it is transferred to the uterus. It allows the specialist to choose the most viable embryo, thereby preventing the birth of a child with genetic defects. It ultimately leads to successful assisted reproduction.
Family Planning & Genetic Health
PGD empowers couples in family planning by enabling the selection of healthy embryos, enhancing the chance of successful pregnancy, and ensuring the birth of a genetically healthy child. It reduces the risk of passing on genetic disorders and allows the couple to make informed decisions.
Choosing Excellence: Why Our PGD Centre Stands Out
Accreditation and Certifications:
Australian Concept is Pakistan’s most successful fertility clinic. We are ISO-certified and have been awarded by Pakistan’s Consumer Association as the best infertility clinic. Our PGD results are 90% accurate, leading to a successful pregnancy.
Experienced Genetic Counselors:We have a team of highly qualified and experienced genetic counsellors who asses the risk and educate our worthy patients. It helps the patients make autonomous and informed decisions regarding genetic testing and family planning.
Success Rates:We have state-of-the-art equipment and highly experienced embryologists for embryo testing. Our embryologists assess each embryo under a microscope for any genetic disorder. Our PGD accuracy rate is 90%, with Pakistan’s most successful pregnancy rate.
Facility and Equipment:To achieve precise and accurate PGD results, we employ cutting-edge technology, including FISH, NGS, SNP, PCR and CGH. We use international standard biopsy tools for safe cell extraction and advanced genetic analyzing software to interpret data accurately.
Location and Accessibility:Australian Concept Lahore is situated at a private site which is easily accessible for all the citizens. We also provide private parking for our patients’ convenience.
Address:Barkat Market, 116-A, near Salar Center, Babar Block Garden Town, Lahore, 54000.
Contact No:+92-304-111-2229
Genetic Disorder Risk Factors:
Couples with a family history of genetic disorders or at high risk of passing on the genetic disorder to the offspring are advised to go for PGD. PGD risks and complications are negligible, and they fade with time
- Advanced Maternal Age
- Closely Related Parents
- Baby with Congenital Disability (s)
- Family History of Genetic Defects
- Previous Recurrent Miscarriages
- Chromosomal Abnormality In Either Parent
Frequently Asked Questions
The cost of PGD in Lahore is around 700k. This cost includes medications, testing, genetic counselling, monitoring, and follow-ups. You can get further information about our PGD package by contacting us at the provided number.
Australian Concept has the highest success rate in assisted reproduction in Pakistan. Our PGD has 90-95% accurate and reliable results, which ultimately help in the selection of healthy embryos and successful pregnancy.
Couples facing recurrent miscarriages, have a family history of genetic disorders, have a child with congenital disabilities, or are closely related can benefit from PGD. Furthermore, couples with either partner of advanced age or has chromosomal abnormality can also go for PGD.
The PGD technique comprises several stages, each performed by an expert under optimal conditions. It can take several weeks to a few months, from initial consultation to embryo transfer.
