Genetics -> PGS
Pre-implantation Genetic Screening
What is a PGS?
The majority of pregnancies, natural or assisted, fail due to aneuploid conceptions. Pre-implantation genetic testing (PGT) is a great way to examine embryos for genetic and chromosomal abnormalities before implantation. Pre-implantation Genetic Screening (PGS) is a type of pre-implantation genetic testing in which embryos are screened for aneuploidy. It is also known as PGT-A, which means pre-implantation genetic testing for aneuploidy. PGS allows the fertility expert to identify the most normal or euploid embryo for implantation. It increases the chance of successful pregnancy and alleviates miscarriage rates. It evaluates all 23 pairs of chromosomes to detect any chromosome-level condition that may be present in an embryo. Australian Concept uses this technique to obtain favorable IVF results.
PGS Procedure and Process
The procedure of PGS comprises several steps performed by experts.
Genetic Testing Method: Genetic testing helps to evaluate embryos created through IVF for any abnormalities before implantation. Pre-implantation genetic screening specifically examines embryos for aneuploidy. It employs comparative genomic hybridization (CGH), an indirect DNA test, which examines all 23 pairs of chromosomes for aneuploidy. Next-generation sequencing (NGS) is the latest technology that can sequence thousands of genes quickly and give reliable results.
Embryo Biopsy: At 3rd or 5th day of development, the embryos are biopsied. An expert removes a few cells from the outer layer of embryos without harming their viability. It is a delicate procedure; hence, the experts at Australian Concept perform it with utmost care and attention. Once the cells are removed, they are sent off for genetic analysis.
Genetic Analysis: The cells removed from the embryos are placed in test tubes and sent to laboratory for evaluation. The cells are analyzed, using NGS or CGH, for any chromosomal aneuploidy. Genetic analysis takes a day usually. It helps fertility experts identify the highest quality embryo for implantation, which reduces the risk of miscarriage and congenital abnormalities.
Selection and Transfer: When the PGS results are obtained, the fertility expert identifies the most euploid embryos for implantation. Only one or two euploid embryos are implanted into the uterus, and the remaining embryos are frozen for future use.
Ethical Considerations: Australian Concept has always been ethical in its practices. We acknowledge the sensitivity of the issue. Therefore, we deal with utmost care when handling genetic information. Besides, we provide complete guidance to our clients to reduce the risk of congenital abnormalities, which helps them make informed decisions.
PGS Success Factors
Genetic Disorder Prevention
PGS has been quite successful in preventing genetic disorders caused by aneuploid embryos. It examines the embryos and helps the fertility experts identify the embryos with the correct number of chromosomes. When the highest quality embryo is implanted into the uterus, it enhances the chance of successful pregnancy and prevents the risk of genetic disorders.
Embryo Viability
PGS increases the chance of successful pregnancy and live birth as it allows fertility experts to identify the most viable embryo. The higher the embryo quality, the higher the chances of healthy pregnancy and childbirth.
Family Planning & Genetic Health
The journey towards parenthood through assisted reproduction is an emotional rollercoaster. In such cases, PGS provides peace of mind to the parents regarding their children's health. Moreover, it identifies the gender of an embryo, which allows the couple to plan their family as per their desire.
Choosing Excellence: Why Our PGS Centre Stands Out
While choosing a PGS center, the couple should assess the reliability of the clinic. With over 20 years of experience, Australian Concept is an ISO-certified fertility clinic with the country's highest success rate in fertility treatments. Our highly qualified professionals provide tailored treatment plans to achieve the desired results. Our experts perform PGS with utmost care to optimize the chances of a healthy pregnancy and live birth.
Experienced Genetic Counselors:Genetic counsellors play an imperative role in the success of fertility treatments. Australian Concept has a team of highly professional genetic counsellors who assess and prevent the risks of passing on congenital abnormalities to offspring and communicate it with prospective parents. They assist our worthy clients in embryo selection, which helps them make informed decisions and family planning.
Success Rates:Australian Concept is the best fertility clinic with the highest fertility treatment success rate nationwide. We have helped 1000s of couples in their journey towards parenthood. We have a 70-80% PGS success rate. Depending upon the history of our worthy clients, we employ this procedure to reduce the chances of aneuploidy and optimize the chances of healthy pregnancy and live birth.
Facility and Equipment:With over two decades of successful experience in the field, Australian Concept uses the most advanced technology to obtain precise and accurate results. Our clinics are well-equipped and meet the international standards of care and safety.
Location and Accessibility:Fertility treatments require frequent visits; therefore, the Australian Concept Infertility Clinic is located at an easily accessible site in Lahore.
Address:Barkat Market, 116-A, near Salar Center, Babar Block Garden Town, Lahore, 54000.
Contact No:+92-304-111-2229
PGS Risks & Considerations
PGS is a safe procedure. However, there are some risks attached to it, which include: PGS risks and complications are negligible, and they fade with time
- Mosaicism
- Examine embryos
- Inconclusive results
- Risk of genetic abnormalities
- Damage to the viability of the embryo during biopsy
Frequently Asked Questions
The PGD technique comprises several stages, each performed by an expert under optimal conditions. It can take several weeks to a few months, from initial consultation to embryo transfer.
Data reveals that PGS has a success rate of 70-80%. The PGS success rate widely depends upon the maternal age. With the increase in maternal age, the chances of PGS success decrease. Studies have shown that the post-PGS live birth rate is lower in women above the age of 35 years as compared to women under the age of 35 years.
